KATHRYN O'REILLY, M.D., PHD. |
Education:
2009- June 2012: NYU Department of Dermatology, Resident, New York, NY
2008-2009: Memorial Sloan-Kettering Cancer Center Transitional Year Internship, New York, NY
2001-2008: Tri-Institutional Weill Cornell/Rockefeller/Sloan-Kettering MD-PhD
Program, New York, NY
PhD, Cell Biology, Weill Cornell Graduate School of Medical Sciences
Dissertation Title: Integration of mTOR and IGF-1 Signaling- Feedback Upregulation of Survival Pathways in Human Cancer Cells, conferred January 2007
Thesis Advisor: Neal Rosen, MD, PhD, Sloan-Kettering Institute
MD, Weill Cornell Medical College, May 2008
1997-2001: Honors B.S. in Biochemistry and B.A. in French, Summa Cum Laude, University of Delaware, Newark, DE
Thesis Project: Novel Ligand-Dependent Control of Nuclear Hormone Receptor Transcription Pathways, Thesis Advisor: John T. Koh, PhD
Research:
2011-2012: Marion Sulzberger Research Fellow, NYU Department of Dermatology
2007-2009: Research Fellow, Department of Dermatology, New York University School of Medicine
Demonstrated that levels of phosphorylated 4E-BP1 correlate with worse survival in melanoma
2003-2006: Graduate Student, Laboratory of Molecular Oncogenesis, Department of Cell Biology, Weill Cornell Graduate School of Medical Sciences/ Sloan-Kettering Institute
Demonstrated that inhibition of mTOR activates upstream receptor
tyrosine kinases and Akt signaling in human cancer cells
Investigated IGF-1-mediated rescue of human cancer cells from 4E-BP1 dephosphorylation and rapamycin-induced translation inhibition
1997-2001: Undergraduate Student, Department of Chemistry and Biochemistry, University of Delaware
Genetically engineered a novel chimeric transcriptional regulator induced by retinoic acid as well as an enhanced reporter plasmid for assay of thyroid hormone-receptor complexes
1996-1998: Howard Hughes Medical Institute Summer Research Intern, Unit on Intracellular Protein Trafficking, National Institute of Child Health and Human Development, NIH, Washington, DC, Advisor- Juan Bonifacino, PhD
Elucidated structure and function of the AP-3 and AP-4 adaptor protein complexes through manual sequencing and mutagenesis as well as the yeast two hybrid assay
1995: Summer Research Intern, Walter Reed Army Institute of Research, Washington, DC
Performed cytotoxicity assays of adenosine analogues with proven anti-HIV activity in immortalized human adipocytes and fibroblasts
Professional Membership:
Fellow, American Academy of Dermatology (since 7/2012)
Fellow, American Society for Dermatologic Surgery (since 7/2012)
Fellow, American Society for Mohs Surgery (since 8/2014)
Medical Licensure:
Delaware, since May 2012
Grants and Fellowships:
2012-2013: Dermatology Foundation Dermatologist Investigator Research Fellowship for
“Targeting Embryonic Signaling Pathways in Melanoma”
2011-2012: NYU Department of Dermatology Sulzberger Research Fellowship
2011-2012: NYU Langone Medical Center Physician Scientist Training Program Grant
2011-2012: Dermatology Foundation Research Award for “Association of Hedgehog Pathway Activation with Melanoma Subtype”
2011- 2012: La Roche-Posay North American Foundation Research Award for “The Role of the
Hedgehog Stem Cell Pathway in Melanoma”
2007-2008: American Skin Association Medical Student Stipend for Targeting Melanoma
2001-2008: NIH Medical Scientist Training Program Grant GM07739
1999-2000: Howard Hughes Medical Institute Undergraduate Research Fellowship
Publications:
O'Reilly KE, de Miera EV, Segura MF, Friedman E, Poliseno L, Han SW, Zhong J, Zavadil J, Pavlick A, Hernando E, Osman I. Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo. Pharmaceuticals (Basel). 2013 Nov11;6(11):1429-50.
Marmon S, O'Reilly KE, Fischer M, Meehan S, Machler B. Papular variant of annular elastolytic giant-cell granuloma. Dermatol Online J. 2012 Dec 15;18(12):23.
Gordon Spratt EA, DeFelice T, O'Reilly K, Robinson M, Patel RR, Sanchez M. Generalized essential telangiectasia. Dermatol Online J. 2012 Dec 15;18(12):13.
Lacouture ME, O'Reilly K, Rosen N, Solit DB. Induction of cutaneous squamous cell carcinomas by RAF inhibitors: cause for concern? J Clin Oncol. 2012 Jan 20;30(3):329-30.
O'Reilly KE, Patel U, Chu J, Patel R, Machler BC. Chemical leukoderma. Dermatol Online J. 2011 Oct 15;17(10):29.
O'Reilly K, Chu J, Meehan S, Heller P, Ashinoff R, Gruson L. Necrobiosis lipoidica. Dermatol Online J. 2011 Oct 15;17(10):18.
Mir A, Tlougan B, O'Reilly K, Tzu J, Meehan S, Kamino H, Franks AG Jr. Morphea with discoid lupus erythematosus. Dermatol Online J. 2011 Oct 15;17(10):10.
O'Reilly K, Brauer J, Loyd A, Patel R, Walters R, Franks AG Jr. Secondary follicular mucinosis associated with systemic lupus erythematosus. Dermatol Online J. 2010 Nov 15;16(11):7.
Hunt R, O'Reilly K, Ralston J, Kamino H, Shupack JL. Familial benign chronic pemphigus (Hailey-Hailey Disease). Dermatol Online J. 2010 Nov 15;16(11):14.
O’Reilly KE, Warycha M, Davies MA, Rodrik V, Zhou XK, Yee H, Polsky D, Pavlick AC, Rosen N, Bhardwaj N, Mills G, Osman I. Phosphorylated 4E-BP1 is associated with poor survival in melanoma.
Clin Cancer Res. 2009 Apr 15;15(8):2872-8.
O’Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006 Feb 1;66(3):1500-8. This article has been referenced over 2000 times by other academic researchers.
She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell. 2005 Oct;8(4):287-97.
Link KH, Cruz FG, Ye HF, O’Reilly KE, Dowdell S, Koh JT. Photo-caged agonists of the nuclear receptors RARgamma and TRbeta provide unique time-dependent gene expression profiles for light-activated gene patterning. Bioorg Med Chem. 2004 Nov 15;12(22):5949-59.
Ye HF, O'Reilly KE, Koh JT. A subtype-selective thyromimetic designed to bind a mutant thyroid hormone receptor implicated in resistance to thyroid hormone. J Am Chem Soc. 2001 Feb 21;123(7):1521-2.
Editorial Review:
Septmber 2009- Present: Reviewer, Journal of Drugs in Dermatology
July 2012- Present: Reviewer, Journal of Cosmetic and Laser Therapy
Conferences:
April 2012: Poster Presentation, American Association for Cancer Research 103rd Annual Meeting (Chicago, IL)
November 2011: Oral Presentation, Ronald O. Perelman Department of Dermatology Research
Day (New York, NY)
February 2011: Oral Presentation, Gross and Microscopic Symposium, American Academy of
Dermatology 69th Annual Meeting (New Orleans, LA)
November 2010: Oral Presentation, Ronald O. Perelman Department of Dermatology Research
Day (New York, NY)
November 2009: Oral Presentation, Ronald O. Perelman Department of Dermatology Tuesday
Night Clinical Conference (New York, NY)
June 2008: Poster Discussion, The American Society of Clinical Oncology 2008 Annual
Meeting (Chicago, IL)
April 2006: Poster Presentation, American Association for Cancer Research 96th
Annual Meeting (Washington, DC)
April 2005: Oral Presentation, American Association for Cancer Research 95th
Annual Meeting (Anaheim, CA)
September 2004: Poster Presentation, 16th Annual EORTC-NCI-AACR Symposium on
Molecular Targets and Cancer Therapeutics (Geneva, Switzerland)
Honors and Awards:
2007: Student Delegate to 46th International Achievement Summit in Washington, DC.
2001: Phi Beta Kappa Honors Society Induction, University of Delaware
2000: Alpha Lambda Delta and Phi Delta Pi (French Language Honor Society) Induction
1999: Phi Beta Kappa Award for Most Distinguished Sophomore, University of Delaware
1998: Kevin Beall Memorial Award for Most Outstanding Freshman in the Chemistry and
Biochemistry Department, University of Delaware
1997-2001: University of Delaware Eugene Du Pont Memorial Distinguished Scholarship